Description

4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-2-Trifluoromethylbenzophenone is a high-value, multifunctional organic intermediate featuring a benzophenone core modified with a spirocyclic acetal-protected amine and a trifluoromethyl group. This unique molecular architecture makes it a critical building block for the synthesis of complex molecules, particularly in advanced pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its spirocyclic amine moiety which can enhance blood-brain barrier penetration.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethyl group confers metabolic stability and lipophilicity.
• Ligand and Catalyst Development: Serves as a sophisticated scaffold for creating chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential building block for advanced polymers or organic electronic materials where the benzophenone unit can act as a photoinitiator or cross-linking agent.
• Chemical Biology Probe Synthesis: Utilized to create tagged or labeled molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-2-Trifluoromethylbenzophenone
CAS No.	898758-10-6
Molecular Formula	C22H22F3NO3
Molecular Weight	405.41 g/mol
Synonyms	2-Trifluoromethyl-4'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]benzophenone; 4'-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylmethyl)-2'-(trifluoromethyl)benzophenone; 1,4-Dioxa-8-azaspiro[4.5]decane, 8-[[4-(2-trifluoromethylbenzoyl)phenyl]methyl]-; 898758-10-6; 4'-(8-(1,4-Dioxa-8-azaspiro[4.5]decyl)methyl)-2-(trifluoromethyl)benzophenone
EINECS	Contact for details

Quality Control

Our production of 4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-2-Trifluoromethylbenzophenone adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive R&D and scale-up processes. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.