Description

4-Carboethoxy-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture that combines benzophenone and spirocyclic ketal-protected amine functionalities. This compound is critically important for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug molecules, especially for neurological and psychiatric applications.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component connecting E3 ligase ligands to target protein binders due to its bifunctional and modifiable structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to introduce specific steric and electronic properties.
• Spirocyclic Compound Synthesis: Provides a protected 1,4-dioxa-8-azaspiro[4.5]decane scaffold, which is a valuable motif in drug design for improving metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the creation of photoaffinity labels or bifunctional probes for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	4-Carboethoxy-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone
CAS No.	898757-70-5
Molecular Formula	C26H31NO5
Molecular Weight	437.53 g/mol
Synonyms	4-(Ethoxycarbonyl)-4'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]benzophenone; 4-Carbethoxy-4'-[8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl]benzophenone; Benzophenone, 4'-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylmethyl)-4-(ethoxycarbonyl)-; 898757-70-5; 4-Carboethoxy-4'-[8-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl]benzophenone; PROTAC Linker intermediate; Spiroketal-protected amine benzophenone derivative.
EINECS	Contact for details

Quality Control

Our 4-Carboethoxy-4'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.