Description

3,4-Dichloro-2'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone is a sophisticated organic intermediate featuring a benzophenone core functionalized with dichloro and spirocyclic acetal-protected amine moieties. This unique molecular architecture makes it a critical building block for the synthesis of complex pharmacologically active compounds, particularly in medicinal chemistry research. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities with potential biological activity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation molecules.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and protein interactions.
• Advanced Organic Synthesis: Employed in multi-step synthetic routes requiring a protected amine and a ketone functional group for further derivatization.
• Agrochemical Research: Investigated as an intermediate for developing new active ingredients with specific modes of action.

Basic Information

Product Name	3,4-Dichloro-2'-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benzophenone
CAS No.	898756-57-5
Molecular Formula	C22H23Cl2NO3
Molecular Weight	420.33 g/mol
Synonyms	2'-(8-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)methyl)-3,4-dichlorobenzophenone; 3,4-Dichloro-2'-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)benzophenone; Benzophenone, 3,4-dichloro-2'-[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-; 3,4-Dichloro-2'-(8-(1,4-dioxa-8-azaspiro[4.5]decyl)methyl)benzophenone; Spirocyclic Benzophenone Derivative; Protected Amine Benzophenone Intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.