Description

2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-2'-Trifluorobenzophenone is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and benzophenone scaffold. This compound is critical for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation therapeutics, where its unique structure enables precise molecular modifications.

Application

• Key Intermediate in CNS Drug Discovery: Serves as a crucial building block for synthesizing potential antipsychotic, antidepressant, and anxiolytic drug candidates.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for new chemical entities (NCEs).
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CRAMOs) for custom synthesis projects.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in API production.

Basic Information

Product Name	2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-2'-Trifluorobenzophenone
CAS No.	898756-27-9
Molecular Formula	C22H22F3NO3
Molecular Weight	405.41 g/mol
Synonyms	2'-(Trifluoromethyl)-2-[[8-(1,4-dioxa-8-azaspiro[4.5]decyl)]methyl]benzophenone; 2-[(8-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl]-2'-(trifluoromethyl)benzophenone; 2-[8-(1,4-Dioxa-8-azaspiro[4.5]decanyl)methyl]-2'-(trifluoromethyl)benzophenone; 898756-27-9; TFMP-Spiroketal Intermediate; Spirocyclic Benzophenone Derivative
EINECS	Contact for details

Quality Control

Every batch of 2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]-2'-Trifluorobenzophenone is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.