Description

3'-Chloro-2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benozphenone is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is primarily needed by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in cutting-edge drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug molecules, especially those targeting neurological pathways.
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry & Scale-Up: Serves as a validated intermediate for the pilot-scale and commercial-scale production of target APIs.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Chemical Biology Probes: Utilized in the development of specialized probes for studying biological receptor interactions and enzyme functions.

Basic Information

Product Name	3'-Chloro-2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benozphenone
CAS No.	898756-00-8
Molecular Formula	C21H22ClNO3
Molecular Weight	371.86 g/mol
Synonyms	3'-Chloro-2-[(8-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)benzophenone; 2-[(8-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-3'-chlorobenzophenone; 898756-00-8; 3'-Chloro-2-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)benzophenone; Benzenone, 3'-chloro-2-[[8-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)]methyl]-; Spirocyclic Benzophenone Derivative
EINECS	Contact for details

Quality Control

Our 3'-Chloro-2-[8-(1,4-Dioxa-8-Azaspiro[4.5]Decyl)Methyl]Benozphenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.