Description

5-Iodo-1H-Pyrrolo[2,3-B]Pyridine is a high-value halogenated heterocyclic building block of significant importance in modern organic synthesis and pharmaceutical research. Its core value lies in enabling the construction of complex molecular architectures, particularly for the development of novel kinase inhibitors and other biologically active compounds. This advanced intermediate is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and life science industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule drugs, especially protein kinase inhibitors.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Biology: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways.
• Material Science: Potential building block for organic electronic materials and functional polymers due to its electron-rich pyrrolopyridine core.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Medicinal Chemistry SAR Studies: Enables rapid exploration of structure-activity relationships by allowing further functionalization at the iodine site.

Basic Information

Product Name	5-Iodo-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	898746-50-4
Molecular Formula	C7H5IN2
Molecular Weight	244.03 g/mol
Synonyms	5-Iodo-7-azaindole; 5-Iodo-1H-pyrrolo[2,3-b]pyridine; 5-Iodo-1H-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 5-iodo-; 5-Iodo-7-aza-indole; 898746-50-4; 5-Iodo-1H-pyrrolo[2,3-b]pyridin
EINECS	Contact for details

Quality Control

Our 5-Iodo-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry characterization. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.