Description

Benzyl 2-{[(Benzyloxy)Carbonyl]Amino}-2-(Dimethoxyphosphoryl)Acetate is a specialized organophosphorus compound featuring a protected amino acid backbone. This molecule serves as a critical building block (synthon) in advanced organic synthesis, particularly for introducing phosphonate and amino acid functionalities. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of protease inhibitors, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of peptide-based drugs and enzyme inhibitors.
• Peptidomimetic Research: Used to construct phosphonate-containing analogs of natural peptides for drug discovery.
• Protease Inhibitor Development: Serves as a core scaffold for creating inhibitors targeting various proteolytic enzymes.
• Medicinal Chemistry: A valuable building block for introducing the phosphonoalanine moiety into novel chemical entities.
• Agrochemical Synthesis: Potential intermediate in the development of novel herbicides or plant growth regulators with phosphonate activity.
• Chemical Biology Probes: Used in the design of activity-based probes for studying enzyme function and mechanism.

Basic Information

Product Name	Benzyl 2-{[(Benzyloxy)Carbonyl]Amino}-2-(Dimethoxyphosphoryl)Acetate
CAS No.	898530-63-7
Molecular Formula	C19H22NO7P
Molecular Weight	407.35 g/mol
Synonyms	Benzyl N-[(Benzyloxy)carbonyl]-P,P-dimethoxyphosphonoglycinate; (Benzyloxycarbonylamino)(dimethoxyphosphoryl)acetic acid benzyl ester; Cbz-PO(OMe)2-Gly-OBzl; Z-PO(OMe)2-Gly-OBzl; N-Carbobenzoxy-P,P-dimethoxyphosphonoglycine benzyl ester; Phosphonoglycine derivative; Benzyl 2-((((benzyloxy)carbonyl)amino)(dimethoxyphosphoryl)acetate
EINECS	Contact for details

Quality Control

Our Benzyl 2-{[(Benzyloxy)Carbonyl]Amino}-2-(Dimethoxyphosphoryl)Acetate is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent levels are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.