Description

Pentafluorophenyl 1-Methyl-1H-Imidazole-4-Carboxylate is a specialized fluorinated heterocyclic building block designed for advanced synthetic chemistry. This compound matters as a high-value reagent, offering a reactive pentafluorophenyl ester group for efficient coupling reactions under mild conditions. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other heterocyclic-based therapeutics.
• Peptide Coupling Reagent: Used as an activating ester for amide bond formation in peptide synthesis and bioconjugation strategies, offering advantages in reactivity and purification.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides that incorporate fluorinated imidazole motifs for enhanced bioactivity and stability.
• Material Science Research: Employed in the creation of functionalized polymers, ligands for catalysis, and advanced organic frameworks (MOFs/COFs) where its fluorine atoms and imidazole core impart unique properties.
• Chemical Biology Probes: Facilitates the labeling and modification of biomolecules for diagnostic and research applications due to its selective reactivity.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions to introduce complex heterocyclic systems.

Basic Information

Product Name	Pentafluorophenyl 1-Methyl-1H-Imidazole-4-Carboxylate
CAS No.	898288-88-5
Molecular Formula	C12H5F5N2O2
Molecular Weight	304.18 g/mol
Synonyms	1-Methyl-1H-imidazole-4-carboxylic acid pentafluorophenyl ester; 4-(1H-Imidazole-4-carboxylic acid), 1-methyl-, 2,3,4,5,6-pentafluorophenyl ester; Pentafluorophenyl 1-methylimidazole-4-carboxylate; 1-Methyl-4-imidazolecarboxylic Acid Pentafluorophenyl Ester; PFP-1-Me-Im-4-CO2; PFP Imidazole Ester; 898288-88-5; CAS 898288-88-5
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 1-Methyl-1H-Imidazole-4-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.