Description

Methyl 1-Boc-3-Methylazetidine-3-Carboxylate is a high-purity, protected azetidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, nitrogen-containing heterocyclic scaffold for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the azetidine ring can contribute to unique biological activity.
• Peptidomimetics & Bioisosteres: The protected carboxylate and amine functionalities make it ideal for constructing peptide analogs and bioisosteric replacements in drug design.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-donor ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic routes in organic chemistry laboratories.
• Custom Synthesis Building Block: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for clients.

Basic Information

Product Name	Methyl 1-Boc-3-Methylazetidine-3-Carboxylate
CAS No.	898228-37-0
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-methylazetidine-3-carboxylic acid methyl ester; Methyl 3-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylate; 3-Methyl-1-Boc-azetidine-3-carboxylic acid methyl ester; 1-Boc-3-methylazetidine-3-carboxylic acid methyl ester; tert-Butyl 3-(methoxycarbonyl)-3-methylazetidine-1-carboxylate; 3-Methylazetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester; Boc-3-methyl-azetidine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 1-Boc-3-Methylazetidine-3-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.