Description

1-(2-Chloro-6-Fluorobenzyl)Piperidine-4-Carboxylic Acid is a high-purity, synthetically valuable pharmaceutical intermediate. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.
• Biochemical Tool Compound: Utilized in pharmacological assays to study specific enzyme or receptor interactions.
• Custom Synthesis: A foundational substrate for the contract synthesis of more complex, proprietary molecules for clients.

Basic Information

Product Name	1-(2-Chloro-6-Fluorobenzyl)Piperidine-4-Carboxylic Acid
CAS No.	897094-28-9
Molecular Formula	C14H17ClFNO2
Molecular Weight	285.74 g/mol
Synonyms	1-[(2-Chloro-6-fluorophenyl)methyl]piperidine-4-carboxylic acid; 4-Piperidinecarboxylic acid, 1-[(2-chloro-6-fluorophenyl)methyl]-; 1-(2-Chloro-6-fluorobenzyl)-4-piperidinecarboxylic Acid; 1-(2-Chloro-6-fluorobenzyl)piperidine-4-carboxylate; 897094-28-9; 1-(2-Chloro-6-fluoro-benzyl)-piperidine-4-carboxylic acid; 1-(2-Chloro-6-fluorobenzyl)isonipecotic acid
EINECS	Contact for details

Quality Control

Our production of 1-(2-Chloro-6-Fluorobenzyl)Piperidine-4-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with ICH Q7 guidelines and can provide material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.