Description

(S)-1-(4-Bromophenyl)-2'-((R)-1-(4-Bromophenyl)-4-Oxo-3,3-Diphenylazetidin-2-Yloxy)-5'-Chloro-3,3-Diphenylspiro[Azetidine-2.3'-Indoline]-4-One is a sophisticated, high-purity chiral spirocyclic compound designed for advanced research and development. This molecule is a critical pharmaceutical intermediate and a valuable building block in medicinal chemistry, particularly for the synthesis of complex bioactive molecules. It is essential for researchers and process chemists in the pharmaceutical and biotechnology industries who require highly specific, enantiomerically pure intermediates for drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its complex, multi-functional spirocyclic and azetidinone architecture.
• Asymmetric Synthesis: Serves as a precursor or template in the development of new asymmetric catalytic reactions and methodologies.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Process Development: Employed in scaling up synthetic routes for potential drug candidates during preclinical and early-phase development.
• Academic Research: A compound of interest for university and institutional research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	(S)-1-(4-Bromophenyl)-2'-((R)-1-(4-Bromophenyl)-4-Oxo-3,3-Diphenylazetidin-2-Yloxy)-5'-Chloro-3,3-Diphenylspiro[Azetidine-2.3'-Indoline]-4-One
CAS No.	896746-45-5
Molecular Formula	C51H35Br2ClN2O3
Molecular Weight	918.60 g/mol
Synonyms	(S)-1-(4-Bromophenyl)-2'-((R)-1-(4-bromophenyl)-4-oxo-3,3-diphenylazetidin-2-yloxy)-5'-chloro-3,3-diphenylspiro[azetidine-2,3'-indolin]-4-one; Spiro[azetidine-2,3'-indoline]-4-one, 1-(4-bromophenyl)-2'-[(1R)-1-(4-bromophenyl)-4-oxo-3,3-diphenyl-2-azetidinyl]oxy]-5'-chloro-3,3-diphenyl-, (2S)-; (S)-5'-Chloro-1-(4-bromophenyl)-2'-((R)-1-(4-bromophenyl)-4-oxo-3,3-diphenylazetidin-2-yloxy)-3,3-diphenylspiro[azetidine-2,3'-indolin]-4-one; 896746-45-5; BRD-K77995004; AOB34034; STK387386; AKOS025310716
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to support your regulatory and research requirements. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are supplied with each shipment. Our quality systems are designed to meet the stringent demands of pharmaceutical R&D and cGMP environments, ensuring traceability and consistency for critical development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.