Description

(S)-1-(4-Bromophenyl)-2'-((R)-1-(4-Bromophenyl)-3,3-Dimethyl-4-Oxoazetidin-2-Yloxy)-3,3,5'-Trimethylspiro[Azetidine-2,3'-Indol]-4-One is a high-purity, complex spirocyclic organic compound featuring a unique azetidine-indole hybrid structure. This compound serves as a critical chiral intermediate in advanced pharmaceutical research and development, enabling the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing next-generation small molecule drugs, particularly in oncology and CNS disorders.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• Asymmetric Synthesis: Employed in the development of stereoselective synthetic routes due to its defined (S) and (R) chiral centers.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study biological pathways and protein interactions.
• Process Chemistry Development: Used for scaling up and optimizing synthetic pathways from laboratory to pilot plant scale.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	(S)-1-(4-Bromophenyl)-2'-((R)-1-(4-Bromophenyl)-3,3-Dimethyl-4-Oxoazetidin-2-Yloxy)-3,3,5'-Trimethylspiro[Azetidine-2,3'-Indol]-4-One
CAS No.	896746-43-3
Molecular Formula	C36H33Br2N3O3
Molecular Weight	707.48 g/mol
Synonyms	(S)-1-(4-Bromophenyl)-2'-((R)-1-(4-bromophenyl)-3,3-dimethyl-4-oxoazetidin-2-yloxy)-3,3,5'-trimethylspiro[azetidine-2,3'-indol]-4-one; Spiro[azetidine-2,3'-indol]-4-one, 1-(4-bromophenyl)-2'-[(1R)-1-(4-bromophenyl)-3,3-dimethyl-4-oxo-2-azetidinyl]oxy]-3,3,5'-trimethyl-, (2'S)-; CAS 896746-43-3; Bromophenyl Dimethyl Oxoazetidinyloxy Trimethylspiroindolone; Chiral Spiro Azetidine Indolone Derivative; Advanced Pharmaceutical Intermediate 896746-43-3.
EINECS	Contact for details

Quality Control

Our (S)-1-(4-Bromophenyl)-2'-((R)-1-(4-Bromophenyl)-3,3-Dimethyl-4-Oxoazetidin-2-Yloxy)-3,3,5'-Trimethylspiro[Azetidine-2,3'-Indol]-4-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet exacting standards for research use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.