Description

(S)-5'-Chloro-1-(4-Bromophenyl)-2'-((S)-1-(4-Chlorophenyl)-4-Oxo-3,3-Diphenylazetidin-2-Yloxy)-3,3-Diphenylspiro[Azetidine-2.3'-Indoline]-4-One is a sophisticated, high-purity chiral spiro compound designed for advanced research and development. This molecule serves as a critical intermediate or building block in the synthesis of complex pharmaceuticals and bioactive molecules, particularly those targeting specific stereochemical pathways. It is essential for pharmaceutical R&D teams, contract research organizations (CROs), and academic research institutions focused on medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry Development: Serves as a reference standard or a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in the development of stereoselective catalytic reactions due to its complex, defined stereochemistry.
• Chemical Biology Probes: Potential use in the design of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	(S)-5'-Chloro-1-(4-Bromophenyl)-2'-((S)-1-(4-Chlorophenyl)-4-Oxo-3,3-Diphenylazetidin-2-Yloxy)-3,3-Diphenylspiro[Azetidine-2.3'-Indoline]-4-One
CAS No.	896746-36-4
Molecular Formula	C51H35BrCl2N2O3
Molecular Weight	866.66 g/mol
Synonyms	(S)-5'-Chloro-1-(4-bromophenyl)-2'-((S)-1-(4-chlorophenyl)-4-oxo-3,3-diphenylazetidin-2-yloxy)-3,3-diphenylspiro[azetidine-2,3'-indolin]-4-one; Spiro[azetidine-2,3'-indoline]-4-one, 5'-chloro-1-(4-bromophenyl)-2'-[(1S)-1-(4-chlorophenyl)-4-oxo-3,3-diphenyl-2-azetidinyl]oxy]-3,3-diphenyl-, (2'S)-; 896746-36-4; BRD-K4477; BRD K4477; BRDK4477; (S,S)-BRD-K4477
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing lot-specific results are available upon request. Our quality systems support development from research to cGMP-grade material for advanced clinical trials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.