Description

(S)-1-(4-Chlorophenyl)-2'-((S)-1-(4-Chlorophenyl)-3,3-Dimethyl-4-Oxoazetidin-2-Yloxy)-3,3,5'-Trimethylspiro[Azetidine-2.3'-Indoline]-4-One is a sophisticated, high-purity chiral spiro compound designed for advanced pharmaceutical research and development. This complex molecule serves as a critical advanced intermediate or building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific biological pathways. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require highly specific stereochemistry and molecular complexity to develop next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block in the research and synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Asymmetric Synthesis: Utilized in the development of stereoselective synthetic methodologies due to its complex, defined stereocenters and spirocyclic architecture.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Item	Detail
Product Name	(S)-1-(4-Chlorophenyl)-2'-((S)-1-(4-Chlorophenyl)-3,3-Dimethyl-4-Oxoazetidin-2-Yloxy)-3,3,5'-Trimethylspiro[Azetidine-2.3'-Indoline]-4-One
CAS No.	896746-34-2
Molecular Formula	C37H35Cl2N3O4
Molecular Weight	656.60 g/mol
Synonyms	(S)-1-(4-Chlorophenyl)-2'-[(S)-1-(4-chlorophenyl)-3,3-dimethyl-4-oxo-2-azetidinyl]oxy-3,3,5'-trimethylspiro[azetidine-2,3'-indoline]-4-one; Spiro[azetidine-2,3'-indoline]-4-one, 1-(4-chlorophenyl)-2'-[(1-(4-chlorophenyl)-3,3-dimethyl-4-oxo-2-azetidinyl)oxy]-3,3,5'-trimethyl-, (2'S,2S)-; (2'S,2S)-1-(4-Chlorophenyl)-2'-[(1-(4-chlorophenyl)-3,3-dimethyl-4-oxo-2-azetidinyl)oxy]-3,3,5'-trimethylspiro[azetidine-2,3'-indoline]-4-one; CAS 896746-34-2; Advanced Spirocyclic Azetidine Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to rigorous quality standards suitable for pharmaceutical R&D. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development under quality agreements and can supply material manufactured in compliance with current Good Manufacturing Practice (cGMP) guidelines for non-clinical and clinical stage applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This compound is likely light-sensitive and may be hygroscopic; therefore, handling under an inert atmosphere and storage with desiccant is recommended for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.