Description

2-Chloro-4-(Trifluoromethyl)Nicotinonitrile is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. This compound matters because its unique trifluoromethyl and chloro-substituted pyridine core enables the precise construction of complex molecules with enhanced biological activity and physicochemical properties. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the scalable production of bespoke, high-value intermediates for client projects.
• Academic & Industrial R&D: Utilized in medicinal chemistry labs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	896447-72-6
Molecular Formula	C7H2ClF3N2
Molecular Weight	206.55 g/mol
Synonyms	2-Chloro-4-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-2-chloro-4-(trifluoromethyl)pyridine; 2-Chloro-4-trifluoromethylnicotinonitrile; 2-Chloro-4-(trifluoromethyl)-3-pyridinecarbonitrile; 3-Pyridinecarbonitrile, 2-chloro-4-(trifluoromethyl)-; 896447-72-6
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Trifluoromethyl)Nicotinonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with client specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.