Description

8-Boc-2-Hydroxy-1-Oxa-8-Azaspiro[4.5]Decane is a sophisticated spirocyclic building block featuring a Boc-protected amine and a hydroxyl group on a 1-oxa-8-azaspiro[4.5]decane scaffold. This compound is highly valued for its structural complexity and versatility in advanced organic synthesis, particularly in medicinal chemistry. It serves as a critical intermediate for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs), especially within therapeutic areas targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those with spirocyclic or bridged heterocyclic architectures.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• CNS Drug Development: Employed in the construction of molecules targeting neurological receptors and enzymes due to its privileged scaffold.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs for the production of bespoke intermediates under cGMP or research-grade conditions.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group provides a stable, orthogonal protecting strategy for amines during multi-step syntheses.
• Chemical Library Development: A valuable scaffold for generating diverse compound libraries for high-throughput screening (HTS) in drug discovery.

Basic Information

Product Name	8-Boc-2-Hydroxy-1-Oxa-8-Azaspiro[4.5]Decane
CAS No.	896103-70-1
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	8-(tert-Butoxycarbonyl)-2-hydroxy-1-oxa-8-azaspiro[4.5]decane; 2-Hydroxy-8-Boc-1-oxa-8-azaspiro[4.5]decane; tert-Butyl 2-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 1-Oxa-8-azaspiro[4.5]decane-2-ol, 8-(1,1-dimethylethyl) ester; 8-Boc-2-hydroxy-1-oxa-8-azaspiro[4.5]decane; Boc-protected spirocyclic amino alcohol.
EINECS	Contact for details

Quality Control

Our 8-Boc-2-Hydroxy-1-Oxa-8-Azaspiro[4.5]Decane is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, for comprehensive characterization and impurity profiling. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with each shipment. Our quality commitment aligns with the standards required for research and development use in pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.