Description

(1S,2S)-2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and cyclopropane architecture. This compound is valued for its role as a critical chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Asymmetric Synthesis: Serves as a sophisticated precursor in catalytic asymmetric reactions to construct complex molecular frameworks.
• Protease Inhibitor Development: Potential application in the synthesis of compounds targeting enzymes like proteases, given its structural motifs.
• Chemical Biology Probes: Can be utilized to create tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	(1S,2S)-2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carbonitrile
CAS No.	895576-36-0
Molecular Formula	C12H10N2O
Molecular Weight	198.22 g/mol
Synonyms	(1S,2S)-2-Cyano-2'-oxospiro[cyclopropane-1,3'-indoline]; (1S,2S)-2-Cyano-2,3-dihydrospiro[cyclopropane-1,3'-indol]-2'-one; (1S,2S)-Spiro[cyclopropane-1,3'-indoline]-2'-one, 2-carbonitrile; (1S-cis)-2'-Oxospiro[cyclopropane-1,3'-indoline]-2-carbonitrile; 895576-36-0; Spiro[cyclopropane-1,3'-indoline]-2-carbonitrile, 2'-oxo-, (1S,2S)-
EINECS	Contact for details

Quality Control

Our (1S,2S)-2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Handle and store under an inert atmosphere (e.g., nitrogen) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.