Description

Spiro[Pyrrolidine-2,7'(6'H)-[2H]Pyrrolo[2,1-B][1,3]Thiazine]-1,4'-Dicarboxylic Acid, Tetrahydro-6'-Oxo-, 1-(1,1-Dimethylethyl) Ester, (2R,4'R,8'Ar)- is a high-purity, stereochemically defined spirocyclic compound that serves as a critical advanced pharmaceutical intermediate (API) and a versatile chiral building block in organic synthesis. Its complex, fused-ring architecture makes it invaluable for constructing sophisticated molecular scaffolds with precise three-dimensional control. This compound is primarily sought by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Asymmetric Synthesis: Employed as a sophisticated chiral auxiliary or building block for constructing stereocenters in medicinal chemistry and process development.
• Protease Inhibitor Research: The spirocyclic and heterocyclic structure is relevant for developing inhibitors of various enzymes, including proteases.
• Chemical Biology & Probe Development: Used to create molecular probes for studying protein function and biological pathways due to its three-dimensional complexity.
• Methodology Development: Serves as a challenging substrate for testing new synthetic methodologies and catalytic systems in academic and industrial R&D.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for custom synthesis houses serving the pharmaceutical and agrochemical industries.

Basic Information

Product Name	Spiro[Pyrrolidine-2,7'(6'H)-[2H]Pyrrolo[2,1-B][1,3]Thiazine]-1,4'-Dicarboxylic Acid, Tetrahydro-6'-Oxo-, 1-(1,1-Dimethylethyl) Ester, (2R,4'R,8'Ar)-
CAS No.	894786-94-8
Molecular Formula	C17H24N2O5S
Molecular Weight	368.45 g/mol
Synonyms	(2R,4'R,8'Ar)-1-(tert-Butyl) Spiro[Pyrrolidine-2,7'(6'H)-[2H]Pyrrolo[2,1-b][1,3]Thiazine]-1,4'-Dicarboxylate, 6'-Oxo-tetrahydro-; tert-Butyl (2R,4'R,8'Ar)-6'-oxo-1',2',3',6'-tetrahydrospiro[pyrrolidine-2,7'-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylate; 894786-94-8; Spirocyclic Pyrrolidine-Thiazine Derivative; (2R,4'R,8aR)-1-tert-butyl 4'-methyl 6'-oxo-1',2',3',6'-tetrahydro-2'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylate (related isomer).
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols suitable for research and pharmaceutical development. Standard quality assurance includes identity confirmation by spectroscopic methods (NMR, IR, MS) and purity determination by HPLC. Our commitment to cGMP principles ensures batch-to-batch consistency and traceability. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and residual solvent levels is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.