Description

Methyl 5-(3-(Trifluoromethyl)Phenyl)Pyridine-3-Carboxylate is a high-value trifluoromethylated pyridine derivative, a key structural motif prized for its ability to modulate the physicochemical properties of advanced molecules. This compound serves as a critical pharmaceutical intermediate and organic building block in the synthesis of complex active ingredients. It is essential for R&D and production teams in the agrochemical, pharmaceutical, and material science sectors seeking to incorporate fluorine chemistry for enhanced bioactivity and stability.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or emitters for OLEDs, due to its conjugated pyridine core and electron-withdrawing substituents.
• Fluorine Chemistry Building Block: A versatile starting material for further functionalization, enabling the introduction of complex fluorinated architectures into target molecules.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	Methyl 5-(3-(Trifluoromethyl)Phenyl)Pyridine-3-Carboxylate
CAS No.	893734-85-5
Molecular Formula	C14H10F3NO2
Molecular Weight	281.23 g/mol
Synonyms	5-[3-(Trifluoromethyl)phenyl]pyridine-3-carboxylic acid methyl ester; Methyl 5-[3-(trifluoromethyl)phenyl]nicotinate; 3-Pyridinecarboxylic acid, 5-[3-(trifluoromethyl)phenyl]-, methyl ester; Methyl 5-(3-trifluoromethylphenyl)nicotinate; 893734-85-5; 5-(3-(Trifluoromethyl)phenyl)nicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-(3-(Trifluoromethyl)Phenyl)Pyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets exacting standards for use in sensitive synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.