Description

Methyl 5-(4-(Trifluoromethyl)Phenyl)Pyridine-3-Carboxylate is a high-value trifluoromethylated pyridine derivative, a key structural motif prized for its ability to modulate the physicochemical properties of advanced molecules. This compound serves as a critical pharmaceutical intermediate and organic synthesis building block for research and development. It is primarily utilized by medicinal chemists and process development scientists in the agrochemical and pharmaceutical industries to create novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a building block for creating sophisticated ligands used in catalysis and molecular recognition studies.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers, due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized to develop fluorescent tags or molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A starting material for custom synthesis projects requiring the introduction of a functionalized pyridine core with a trifluoromethylphenyl group.

Basic Information

Product Name	Methyl 5-(4-(Trifluoromethyl)Phenyl)Pyridine-3-Carboxylate
CAS No.	893734-81-1
Molecular Formula	C14H10F3NO2
Molecular Weight	281.23 g/mol
Synonyms	5-[4-(Trifluoromethyl)phenyl]pyridine-3-carboxylic acid methyl ester; Methyl 5-[4-(trifluoromethyl)phenyl]nicotinate; 3-Pyridinecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-, methyl ester; 5-(4-Trifluoromethylphenyl)nicotinic acid methyl ester; 893734-81-1; Methyl 5-(4-trifluoromethylphenyl)nicotinate
EINECS	Contact for details

Quality Control

Our Methyl 5-(4-(Trifluoromethyl)Phenyl)Pyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.