Description

2-Bromo-6-(Tetrahydropyran-4-Yloxy)Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where precise molecular architecture is paramount. Its primary utility lies in serving as a key intermediate in cross-coupling reactions and as a scaffold for constructing complex molecules. This product is essential for pharmaceutical R&D, agrochemical discovery, and advanced material science applications requiring high-purity, specialized intermediates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides requiring specific bromo- and pyridine-based motifs.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: An essential substrate for Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to form biaryl and complex heterocyclic systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and target engagement.
• Ligand Synthesis: Acts as a precursor for creating novel chiral and achiral ligands used in asymmetric catalysis and metal complexation.

Basic Information

Product Name	2-Bromo-6-(Tetrahydropyran-4-Yloxy)Pyridine
CAS No.	892502-16-8
Molecular Formula	C10H12BrNO2
Molecular Weight	258.11 g/mol
Synonyms	2-Bromo-6-((tetrahydro-2H-pyran-4-yl)oxy)pyridine; 6-Bromo-2-(tetrahydropyran-4-yloxy)pyridine; Pyridine, 2-bromo-6-(tetrahydro-2H-pyran-4-yloxy)-; THP-Protected 6-Bromo-2-hydroxypyridine; 2-Bromo-6-(oxan-4-yloxy)pyridine; 892502-16-8; 2-Bromo-6-(THP-oxy)pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6-(Tetrahydropyran-4-Yloxy)Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports compliance in cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.