Description

4-[5-(Trifluoromethyl)Pyrid-2-Yl]Benzonitrile is a high-value, multi-functional heterocyclic building block featuring a pyridine core linked to a benzonitrile group via a phenyl bridge, with a strategically positioned trifluoromethyl substituent. This compound matters for its unique combination of electronic properties, lipophilicity, and metabolic stability imparted by the trifluoromethyl group, making it a critical intermediate in advanced synthesis. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functional organic materials, including liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology Probe Development: Employed as a scaffold for creating molecular probes and tags to study biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring complex fluorinated heterocycles.

Basic Information

Product Name	4-[5-(Trifluoromethyl)Pyrid-2-Yl]Benzonitrile
CAS No.	892501-99-4
Molecular Formula	C13H7F3N2
Molecular Weight	248.21 g/mol
Synonyms	2-[4-(Cyanophenyl)]-5-(trifluoromethyl)pyridine; 4-(5-(Trifluoromethyl)pyridin-2-yl)benzonitrile; 2-(4-Cyanophenyl)-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-(4-cyanophenyl)pyridine; [4-(5-Trifluoromethyl-2-pyridyl)phenyl]acetonitrile (incorrect but common misnomer); 892501-99-4; 4-(5-Trifluoromethylpyridin-2-yl)benzonitrile
EINECS	Contact for details

Quality Control

Our 4-[5-(Trifluoromethyl)Pyrid-2-Yl]Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.