Description

Benzenamine, 4-[[6-Chloro-3-(trifluoromethyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro- is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis. This compound is critical for researchers and manufacturers developing novel therapeutic agents, particularly in oncology and other targeted therapy areas. Its complex molecular architecture, featuring a pyrrolopyridine core with strategic halogen and silyl ether protecting groups, makes it an essential building block for constructing potent and selective drug candidates. CAS 892414-55-0.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex small-molecule active pharmaceutical ingredients (APIs), particularly kinase inhibitors and other targeted cancer therapies.
• Research & Development (R&D): Used in medicinal chemistry for lead optimization and structure-activity relationship (SAR) studies in drug discovery programs.
• Process Chemistry: Serves as a critical building block in the scale-up and commercial manufacturing processes for new chemical entities (NCEs).
• Biochemical Research: Employed in the development of chemical probes and tool compounds for studying specific biological pathways and protein functions.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for the production of specialized compounds for client projects.

Basic Information

Product Name	Benzenamine, 4-[[6-Chloro-3-(trifluoromethyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-
CAS No.	892414-55-0
Molecular Formula	C24H22ClF5N3O2Si
Molecular Weight	542.00 g/mol
Synonyms	4-((6-Chloro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluoroaniline; 3,5-Difluoro-4-((6-chloro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)benzenamine; 892414-55-0; SEM-Protected Pyrrolopyridine Intermediate; 4-Amino-2,6-difluorophenyl pyrrolopyridinyl ether derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support our partners in meeting the stringent requirements of cGMP and ICH guidelines for drug substance manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.