Description

1H-Pyrrolo[2,3-B]Pyridin-3-Ol, 2,3-Dihydro-3-(Trifluoromethyl)- is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique pyrrolopyridine scaffold modified with a trifluoromethyl group, which is critical for modulating the physicochemical and biological properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a privileged scaffold in medicinal chemistry for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used as a key building block in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Employed in the synthesis of specialized organic electronic materials and ligands for catalysis due to its electron-deficient aromatic system.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridin-3-Ol, 2,3-Dihydro-3-(Trifluoromethyl)-
CAS No.	892414-46-9
Molecular Formula	C8H7F3N2O
Molecular Weight	204.15 g/mol
Synonyms	2,3-Dihydro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-ol; 3-(Trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol; 3-Hydroxy-3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; Fluorinated Pyrrolopyridinol; Trifluoromethyl Dihydro Pyrrolopyridinol; Building Block 892414-46-9; CAS 892414-46-9
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridin-3-Ol, 2,3-Dihydro-3-(Trifluoromethyl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound may be sensitive to strong bases and fluorides; incompatible materials should be stored separately. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.