Description

3-Pyridinemethanol,2-Fluoro-α-(Nitromethyl)-α-(Trifluoromethyl)- is a high-value, multi-functionalized pyridine derivative designed for advanced synthetic applications. This compound is critical for research and development in pharmaceutical chemistry, serving as a sophisticated building block for creating novel active ingredients. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate unique fluorinated and nitromethyl motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, high-performance crop protection agents with improved efficacy and environmental profiles.
• Ligand & Catalyst Development: Serves as a precursor for novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorinated Compound Library: An essential component for building diverse screening libraries in drug discovery programs focused on fluorinated molecules.
• Material Science Research: Investigated for incorporation into specialty polymers and advanced organic materials requiring specific electronic properties.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of complex target molecules.

Basic Information

Item	Detail
Product Name	3-Pyridinemethanol,2-Fluoro-α-(Nitromethyl)-α-(Trifluoromethyl)-
CAS No.	892414-45-8
Molecular Formula	C8H6F4N2O3
Molecular Weight	254.14 g/mol
Synonyms	2-Fluoro-α-(nitromethyl)-α-(trifluoromethyl)-3-pyridinemethanol; (2-Fluoropyridin-3-yl)(trifluoromethyl)(nitromethyl)methanol; α-(Nitromethyl)-α-(trifluoromethyl)-2-fluoropyridine-3-methanol; 2-Fluoro-α-(nitromethyl)-α-(trifluoromethyl)-3-pyridylmethanol; 3-Pyridinemethanol, 2-fluoro-α-(nitromethyl)-α-(trifluoromethyl)-; (2-Fluoro-3-pyridinyl)(trifluoromethyl)(nitromethyl)methanol
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinemethanol,2-Fluoro-α-(Nitromethyl)-α-(Trifluoromethyl)- is produced under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay purity and impurity profiles as determined by HPLC, NMR, and MS. Our quality commitment aligns with cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.