Description

1'H-Spiro[Cycloheptane-1,2'-Quinazoline]-4'-Thiol is a specialized spirocyclic quinazoline derivative, a high-value chemical intermediate prized for its unique molecular architecture. This compound matters for its role as a critical building block in advanced pharmaceutical research and development, particularly in the synthesis of novel drug candidates. Industries that need it include pharmaceutical R&D, agrochemical innovators, and academic institutions focused on medicinal chemistry and heterocyclic compound synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel therapeutic agents, particularly those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) in drug discovery programs.
• Agrochemical Development: Serves as a building block for creating new crop protection agents and pesticides with novel modes of action.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and enzyme functions due to its reactive thiol group.
• Material Science Research: Investigated as a potential monomer or additive for creating advanced polymers with specific optical or electronic properties.

Basic Information

Product Name	1'H-Spiro[Cycloheptane-1,2'-Quinazoline]-4'-Thiol
CAS No.	892299-03-5
Molecular Formula	C₁₅H₁₈N₂S
Molecular Weight	258.38 g/mol
Synonyms	4'-Mercapto-1'H-spiro[cycloheptane-1,2'-quinazoline]; 1'H-Spiro(cycloheptane-1,2'-quinazoline)-4'-thiol; Spiro[cycloheptane-1,2'-quinazoline]-4'-thiol; 892299-03-5; 4'-Thio-1'H-spiro[cycloheptane-1,2'-quinazoline]; 1'H-Spiro[cycloheptane-1,2'-[2H]quinazoline]-4'-thiol; 4'-Sulfanyl-1'H-spiro[cycloheptane-1,2'-quinazoline]
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. For this high-purity intermediate, quality is assured through multiple analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.