Description

Ceralifimod CAS NO 891859-12-4 is a high-purity, small molecule pharmaceutical intermediate and research chemical. This compound is of significant interest in the development of novel immunomodulatory therapies, particularly as a selective sphingosine-1-phosphate (S1P) receptor modulator. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of advanced active pharmaceutical ingredients (APIs) for clinical research and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation S1P receptor-targeting therapeutics.
• Immunology Research: Used as a reference standard or active compound in preclinical studies investigating autoimmune diseases, multiple sclerosis, and transplant rejection.
• Process Chemistry & Scale-Up: Serves as a critical material for route scouting, optimization, and pilot-scale manufacturing of candidate drugs.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to study S1P receptor pharmacology.
• Academic Research: Utilized in university and institutional labs for fundamental research on sphingolipid signaling pathways.
• GMP Starting Material: Suitable for further processing under Good Manufacturing Practice (GMP) guidelines for clinical trial material production.

Basic Information

Product Name	Ceralifimod
CAS No.	891859-12-4
Molecular Formula	C₂₀H₂₃FN₂O₃
Molecular Weight	358.41 g/mol
Synonyms	2-[(3S)-3-[(1E)-1-(4-Cyclohexyl-3-trifluoromethylbenzyloxyimino)ethyl]-2,3-dihydro-1,4-benzodioxin-6-yl]-N-(3-fluorophenyl)acetamide; Ceralifimod; ACT-128800; 2-[(3S)-3-[(1E)-1-[[[4-(Cyclohexyl)-3-(trifluoromethyl)phenyl]methoxy]imino]ethyl]-2,3-dihydro-1,4-benzodioxin-6-yl]-N-(3-fluorophenyl)acetamide; S1P1 Receptor Agonist ACT-128800
EINECS	Contact for details

Quality Control

Every batch of Ceralifimod is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting regulatory filings and process validation. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (HPLC), chiral purity, and related substances. Our quality commitment aligns with ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a controlled humidity environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.