Description

6-(Cyclobutoxy)-2-Bromopyridine is a high-purity brominated pyridine derivative, serving as a versatile and critical building block in advanced organic synthesis. Its molecular structure, featuring both a bromine substituent and a cyclobutoxy ether linkage, makes it an essential intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic core.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands in transition metal catalysis and organocatalysts.
• Material Science Research: Building block for the synthesis of organic electronic materials, such as charge-transport molecules or liquid crystals.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig cross-coupling reactions to form new carbon-carbon and carbon-heteroatom bonds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	6-(Cyclobutoxy)-2-Bromopyridine
CAS No.	891842-80-1
Molecular Formula	C9H10BrNO
Molecular Weight	228.09 g/mol
Synonyms	2-Bromo-6-cyclobutoxypyridine; 2-Bromo-6-(cyclobutyloxy)pyridine; 6-Cyclobutoxy-2-bromopyridine; Pyridine, 2-bromo-6-(cyclobutyloxy)-; 891842-80-1; 2-Bromopyridine, 6-(cyclobutoxy)-; 6-(Cyclobutoxy)-2-bromo-pyridine
EINECS	Contact for details

Quality Control

Every batch of 6-(Cyclobutoxy)-2-Bromopyridine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed impurity profiling available. Certificates of Analysis (COA) are provided with each shipment, documenting key parameters such as identity, assay, and related substances. We support development and scale-up projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.