Description

3-(Methylsulfonyl)-2,5-Dioxopyrrolidin-1-Yl 4-((5-Nitropyridin-2-Yl)Disulfanyl)Pentanoate is a specialized heterocyclic compound featuring a disulfide linker and an activated ester group, making it a valuable intermediate for advanced chemical synthesis. Its primary commercial value lies in its role as a key building block for the development of pharmaceuticals, particularly in the creation of targeted drug conjugates and prodrugs. This compound is essential for research and development teams in the pharmaceutical, agrochemical, and life science reagent sectors seeking to incorporate cleavable, functionalized molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel active pharmaceutical ingredients (APIs), especially in prodrug and targeted drug delivery system development.
• Bioconjugation Reagent: Used for creating antibody-drug conjugates (ADCs) and other bioconjugates, leveraging its cleavable disulfide bond and reactive NHS ester for linking payloads to targeting molecules.
• Proteolysis-Targeting Chimera (PROTAC) Linker: Serves as a component in the design of PROTACs and other bifunctional molecules, where the disulfide bond can be utilized for controlled degradation.
• Chemical Biology Research: Employed in research tools and probes for studying protein function, cellular uptake, and redox-sensitive release mechanisms.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for synthesizing smart polymers with stimuli-responsive (e.g., redox-sensitive) properties.
• Agrochemical Synthesis: Intermediate in the development of advanced crop protection agents with specific release profiles.

Basic Information

Product Name	3-(Methylsulfonyl)-2,5-Dioxopyrrolidin-1-Yl 4-((5-Nitropyridin-2-Yl)Disulfanyl)Pentanoate
CAS No.	890409-87-7
Molecular Formula	C15H15N3O8S3
Molecular Weight	477.49 g/mol
Synonyms	4-((5-Nitropyridin-2-yl)disulfanyl)pentanoic acid 2,5-dioxopyrrolidin-1-yl 3-(methylsulfonyl) ester; 1-[(3-Methanesulfonyl-2,5-dioxo-pyrrolidin-1-yl)]-4-[(5-nitro-2-pyridyl)dithio]butyrate; N-(3-Methylsulfonyl-succinimidyl) 4-((5-nitropyridin-2-yl)dithio)butyrate; N-Succinimidyl 3-(Methylsulfonyl) 4-((5-Nitropyridin-2-yl)Disulfanyl)Butyrate; 3-Methanesulfonyl-N-succinimidyl 4-((5-nitropyridin-2-yl)dithio)butanoate; MS-Nosyl-SS-butyrate-OSu; SSA (Sulfosuccinimidyl active ester) derivative with disulfide pyridine linker.
EINECS	Contact for details

Quality Control

Our production of 3-(Methylsulfonyl)-2,5-Dioxopyrrolidin-1-Yl 4-((5-Nitropyridin-2-Yl)Disulfanyl)Pentanoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical R&D and cGMP manufacturing applications. Each lot undergoes comprehensive analytical characterization including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.