Description

2-(4-Boc-Piperazino)-2-(2-Pyridyl)Acetic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a Boc-protected piperazine ring and a pyridyl-acetate ester moiety. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for targeted therapies. It is essential for medicinal chemistry research and process development in the pharmaceutical and biotechnology industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Process Chemistry & Scale-up: Serves as a validated building block for pilot plant and commercial-scale API manufacturing under GMP conditions.
• Protease Inhibitor Synthesis: Employed in constructing complex molecules that interact with specific enzymatic targets.
• Chemical Biology Probes: Utilized to create labeled or tagged compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific novel chemical entities (NCEs).

Basic Information

Item	Details
Product Name	2-(4-Boc-Piperazino)-2-(2-Pyridyl)Acetic Acid Methyl Ester
CAS No.	890090-44-5
Molecular Formula	C17H25N3O4
Molecular Weight	335.40 g/mol
Synonyms	Methyl 2-(4-((tert-butoxycarbonyl)amino)piperazin-1-yl)-2-(pyridin-2-yl)acetate; 2-(4-Boc-Piperazino)-2-(2-Pyridyl)Acetic Acid Methyl Ester; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-(pyridin-2-yl)acetic acid methyl ester; tert-Butyl 4-(2-methoxy-1-(pyridin-2-yl)-2-oxoethyl)piperazine-1-carboxylate; 890090-44-5; Boc-Pip-Py-Ome; (2-Pyridyl)(4-Boc-piperazinyl)acetic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-(4-Boc-Piperazino)-2-(2-Pyridyl)Acetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results. We support development and commercial projects requiring material suitable for use under ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.