Description

1-Boc-4-Ethylidene-Piperidine is a versatile and high-purity protected piperidine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a reactive ethylidene handle while the Boc (tert-butoxycarbonyl) group offers orthogonal protection for the amine, enabling complex, multi-step synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, especially in medicinal chemistry programs targeting CNS disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the piperidine scaffold is a common structural motif.
• Chemical Research & Development: A valuable reagent for constructing spirocyclic and bridged nitrogen-containing heterocycles in academic and industrial R&D labs.
• Peptidomimetics & Bioconjugation: Facilitates the introduction of lipophilic or reactive moieties into peptide backbones or for creating bioconjugation linkers.
• Material Science Precursor: Potential use as a monomer or functionalizing agent in the synthesis of specialized polymers and advanced materials.

Basic Information

Product Name	1-Boc-4-Ethylidene-Piperidine
CAS No.	889955-48-0
Molecular Formula	C12H21NO2
Molecular Weight	211.30 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-ethylidenepiperidine; tert-Butyl 4-ethylidene-1-piperidinecarboxylate; 4-Ethylidene-1-piperidinecarboxylic acid tert-butyl ester; 1-Boc-4-ethylidenepiperidine; N-Boc-4-ethylidenepiperidine; Boc-4-ethylidenepiperidine; 1-(tert-Butyloxycarbonyl)-4-ethylidenepiperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Ethylidene-Piperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.