Description

5-Chloro-6-Piperazin-1-Yl-Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate with a distinct heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, especially within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Chemical Synthesis: Serves as a versatile precursor for constructing complex piperazine-containing heterocycles in organic synthesis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Bioconjugation: Potential use in creating targeted drug conjugates due to its functionalizable carboxylic acid group.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	5-Chloro-6-Piperazin-1-Yl-Nicotinic Acid
CAS No.	889953-74-6
Molecular Formula	C10H11ClN4O2
Molecular Weight	254.67 g/mol
Synonyms	5-Chloro-6-(piperazin-1-yl)nicotinic acid; 5-Chloro-6-piperazin-1-ylpyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-chloro-6-(1-piperazinyl)-; 889953-74-6; 5-Chloro-6-piperazin-1-yl-nicotinic acid; 6-Piperazin-1-yl-5-chloronicotinic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Piperazin-1-Yl-Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.