Description

3-Carboxymethoxy-Azetidine-1-Carboxylic Acid Benzyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine ring system. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other targeted therapeutics. It is essential for R&D and production teams in pharmaceutical, biotechnology, and fine chemical sectors seeking to build complex, nitrogen-containing heterocycles with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly protease inhibitors and enzyme modulators.
• Peptidomimetic Research: Used to construct constrained peptide analogs and macrocycles to improve metabolic stability and bioavailability.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in target identification and mechanism-of-action studies.
• Agrochemical Development: Potential intermediate for creating new crop protection agents with novel modes of action.
• Material Science: Exploration as a monomer or cross-linker for specialty polymers with specific functional properties.

Basic Information

Product Name	3-Carboxymethoxy-Azetidine-1-Carboxylic Acid Benzyl Ester
CAS No.	889952-98-1
Molecular Formula	C13H15NO5
Molecular Weight	265.26 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-(carboxymethoxy)azetidine; 3-(Carboxymethoxy)azetidine-1-carboxylic acid benzyl ester; Benzyl 3-(carboxymethoxy)azetidine-1-carboxylate; Azetidine-1-carboxylic acid, 3-(carboxymethoxy)-, benzyl ester; 889952-98-1; 1-CBZ-3-carboxymethoxyazetidine
EINECS	Contact for details

Quality Control

Our production of 3-Carboxymethoxy-Azetidine-1-Carboxylic Acid Benzyl Ester adheres to stringent quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), residual solvents, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.