Description

6-Chloro-4-Methylpyridine-3-Sulfonyl Chloride is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in its dual reactive sites—the sulfonyl chloride and chloro substituents—which enable precise derivatization and the construction of complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to construct pyridine-sulfonamide scaffolds found in modern herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or cross-linking agent for developing specialty polymers and functional materials.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation, labeling proteins, or creating activity-based probes.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the bespoke production of complex, high-value intermediates for client projects.
• Academic & R&D Laboratories: Fundamental building block for methodological development and exploring new chemical reactions in heterocyclic chemistry.

Basic Information

Product Name	6-Chloro-4-Methylpyridine-3-Sulfonyl Chloride
CAS No.	889944-76-7
Molecular Formula	C7H7Cl2NO2S
Molecular Weight	240.11 g/mol
Synonyms	3-Chlorosulfonyl-6-chloro-4-methylpyridine; 6-Chloro-4-methyl-3-pyridinesulfonyl chloride; 4-Methyl-6-chloropyridine-3-sulfonyl chloride; 3-Pyridinesulfonyl chloride, 6-chloro-4-methyl-; 6-Chloro-4-methylpyridine-3-sulfonylchloride; 889944-76-7 (CAS); 6-Chloro-4-methyl-3-sulfonylchloridopyridine
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-4-Methylpyridine-3-Sulfonyl Chloride undergoes rigorous analytical testing to ensure it meets the stringent purity and consistency requirements for synthetic applications. Our quality assurance protocols are designed to support cGMP and ISO standards where applicable. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.