Description

6-Hydroxyspiro[3.3]heptane-2-carboxylic acid is a high-value, multifunctional spirocyclic building block with a unique three-dimensional structure. This compound is critical for medicinal chemistry research, enabling the synthesis of novel molecules with enhanced biological activity and improved physicochemical properties. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for applications in drug discovery and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a versatile linker or component in the design of bifunctional molecules for targeted protein degradation.
• Ligand Synthesis for Catalysis: Serves as a precursor for creating sophisticated chiral ligands used in asymmetric synthesis and transition metal catalysis.
• Advanced Material Science: Employed in the synthesis of specialty monomers and polymers with unique structural and mechanical properties.
• Agrochemical Research: Acts as a building block for developing new crop protection agents with novel modes of action.
• Chemical Biology Probes: Utilized to construct molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	6-Hydroxyspiro[3.3]heptane-2-carboxylic Acid
CAS No.	889944-59-6
Molecular Formula	C9H12O3
Molecular Weight	168.19 g/mol
Synonyms	6-Hydroxyspiro[3.3]heptane-2-carboxylic acid; 2-Carboxy-6-hydroxyspiro[3.3]heptane; 6-Hydroxy-2-spiro[3.3]heptanecarboxylic acid; 6-Hydroxyspiro[3.3]heptane-2-carboxylate; 6-Hydroxy-2-carboxyspiro[3.3]heptane; 6-Hydroxy-2-spiro[3.3]heptane carboxylic acid; 6-Hydroxyspiro[3.3]heptane-2-carboxylicacid; 6-Hydroxy-2-carboxyspiro[3.3]heptane
EINECS	Contact for details

Quality Control

Our 6-Hydroxyspiro[3.3]heptane-2-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. Due to its hygroscopic nature, the container must be kept sealed and handled in a moisture-controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.