Description

1-[6-(Trifluoromethyl)[1,2,4]Triazolo[4,3-A]Pyridin-3-Yl]Methanamine is a high-value, nitrogen-rich heterocyclic building block featuring a fused triazolopyridine core and a reactive primary amine group. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, enabling the introduction of key pharmacophores. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl and triazole groups contribute to biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced polymers, ligands for catalysis, and organic electronic materials.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for designing enzyme inhibitors or receptor modulators.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	1-[6-(Trifluoromethyl)[1,2,4]Triazolo[4,3-A]Pyridin-3-Yl]Methanamine
CAS No.	889943-45-7
Molecular Formula	C8H5F3N4
Molecular Weight	214.15 g/mol
Synonyms	1-(6-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine; 3-(Aminomethyl)-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine; 6-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-methanamine; 889943-45-7; 1-(6-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridin-3-yl)methanamine
EINECS	Contact for details

Quality Control

Our 1-[6-(Trifluoromethyl)[1,2,4]Triazolo[4,3-A]Pyridin-3-Yl]Methanamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We can supply material suitable for research and development as well as grades aligned with cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.