Description

4-Bromo-2-Iodo-1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-halogenated pyrrolopyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in enabling the precise construction of complex nitrogen-containing heterocycles, which are pivotal scaffolds in modern drug discovery. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for those focused on kinase inhibitor programs and the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential kinase inhibitors and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the development of novel active ingredients for crop protection, leveraging its complex heterocyclic structure.
• Chemical Biology Probe Synthesis: Employed to create tagged or modified molecular probes for studying biological processes and target engagement.
• Material Science Precursor: Serves as a starting material for synthesizing specialized organic electronic materials or ligands for catalysis.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry.

Basic Information

Item	Details
Product Name	4-Bromo-2-Iodo-1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	889939-26-8
Molecular Formula	C13H8BrIN2O2S
Molecular Weight	462.09 g/mol
Synonyms	1-(Benzenesulfonyl)-4-bromo-2-iodo-1H-pyrrolo[2,3-b]pyridine; 4-Bromo-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-bromo-2-iodo-1-(phenylsulfonyl)-; 4-Bromo-2-iodo-1H-pyrrolo[2,3-b]pyridine 1-(phenylsulfonyl) derivative; N-Phenylsulfonyl-4-bromo-2-iodo-7-azaindole
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Iodo-1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our processes are designed to support cGMP (current Good Manufacturing Practice) standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (typically 15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.