Description

5-Bromo-2-Chloropyridine N-Oxide is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its unique reactivity, enabling the introduction of both bromo and chloro substituents in a controlled manner on the pyridine N-oxide scaffold. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the halogenated pyridine core is essential for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials and functionalized polymers.
• Cross-Coupling Reactions: The bromo and chloro groups provide orthogonal reactivity for sequential Suzuki, Stille, or Buchwald-Hartwig amination reactions.
• Chemical Biology Probes: Useful for tagging and modifying biomolecules in probe development and bioconjugation strategies.

Basic Information

Product Name	5-Bromo-2-Chloropyridine N-Oxide
CAS No.	889865-43-4
Molecular Formula	C5H3BrClNO
Molecular Weight	208.44 g/mol
Synonyms	2-Chloro-5-bromopyridine 1-oxide; 5-Bromo-2-chloropyridine 1-oxide; 2-Chloro-5-bromopyridine N-oxide; 5-Bromo-2-chloro-1-oxidopyridin-1-ium; Pyridine, 5-bromo-2-chloro-, 1-oxide
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloropyridine N-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.