Description

1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylicacid,1,1-Dimethylethylester CAS NO 889451-30-3 is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyridine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its role in synthesizing novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold for constructing complex APIs, leveraging its fused heterocyclic structure for optimal bioactivity.
• Medicinal Chemistry & Drug Discovery: Utilized in high-throughput screening and structure-activity relationship (SAR) studies to develop new chemical entities.
• Biochemical Research: Employed as a standard or reagent in biochemical assays and pharmacological studies investigating enzyme inhibition or receptor binding.
• Contract Research and Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects and scale-up development under cGMP guidelines.

Basic Information

Product Name	1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylicacid,1,1-Dimethylethylester
CAS No.	889451-30-3
Molecular Formula	C13H15N3O2
Molecular Weight	245.28 g/mol
Synonyms	tert-Butyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate; 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid, 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-1H-pyrazolo[3,4-b]pyridine; Pyrazolo[3,4-b]pyridine-3-carboxylic acid tert-butyl ester; tert-Butyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate; 889451-30-3; tert-Butyl pyrazolo[3,4-b]pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylicacid,1,1-Dimethylethylester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) documenting full specifications are available upon request, and custom synthesis to meet specific pharmacopeial or internal standards can be arranged.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.