Description

1-(4-Fluorophenyl)-n-[3-Fluoro-4-(1H-Pyrrolo[2,3-B]Pyridin-4-Yloxy)Phenyl]-1,2-Dihydro-2-Oxo-3-Pyridinecarboxamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the research and development of novel, targeted therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of innovative small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Oncology Drug Discovery: Used in the research and development of targeted cancer therapies, leveraging its specific molecular scaffold for kinase inhibition or other mechanisms.
• Biochemical Research: Employed as a reference standard or a probe compound in biochemical assays to study protein-ligand interactions and cellular pathways.
• Preclinical Development: Essential for producing batches of active pharmaceutical ingredients (APIs) required for pharmacological and toxicological studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global biopharma industry.
• Academic Research: Utilized in university and institutional labs for cutting-edge medicinal chemistry projects and publications.

Basic Information

Product Name	1-(4-Fluorophenyl)-n-[3-Fluoro-4-(1H-Pyrrolo[2,3-B]Pyridin-4-Yloxy)Phenyl]-1,2-Dihydro-2-Oxo-3-Pyridinecarboxamide
CAS No.	888719-03-7
Molecular Formula	C25H16F2N4O3
Molecular Weight	458.42 g/mol
Synonyms	4-Fluoro-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide; 1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydro-3-pyridinecarboxamide; UNII-1G2Q8N791N; 1G2Q8N791N; BMS-777607; BMS777607; AS-252424; Foretinib intermediate; GSK1363089 intermediate
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorophenyl)-n-[3-Fluoro-4-(1H-Pyrrolo[2,3-B]Pyridin-4-Yloxy)Phenyl]-1,2-Dihydro-2-Oxo-3-Pyridinecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and early-stage development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.