Description

tert-Butyl N-[6-(Bromomethyl)-2-Pyridyl]-N-tert-butoxycarbonyl-carbamate is a specialized, high-purity chemical intermediate featuring both a bromomethyl group and a Boc-protected amine on a pyridine scaffold. This compound is valued for its dual functionality, enabling selective alkylation and subsequent deprotection in complex synthetic sequences. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of small molecule drug candidates, particularly those targeting kinase inhibition or requiring pyridine-based pharmacophores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where its reactive bromomethyl group allows for structural diversification.
• Ligand and Catalyst Preparation: Serves as a precursor for creating sophisticated pyridyl-based ligands used in transition metal catalysis and organometallic chemistry.
• Peptidomimetic and PROTAC Development: The Boc-protected amine is instrumental in constructing peptide-like structures and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Material Science Research: Employed in the synthesis of functionalized polymers or metal-organic frameworks (MOFs) that incorporate nitrogen-containing heterocycles.
• Cross-Coupling Reactions: The bromomethyl moiety can be utilized in various palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.

Basic Information

Product Name	tert-Butyl N-[6-(Bromomethyl)-2-Pyridyl]-N-tert-butoxycarbonyl-carbamate
CAS No.	888322-11-0
Molecular Formula	C16H23BrN2O4
Molecular Weight	387.27 g/mol
Synonyms	tert-Butyl N-(6-(bromomethyl)pyridin-2-yl)-N-[(tert-butoxy)carbonyl]carbamate; 2-Pyridinecarboxamide, N-[6-(bromomethyl)-2-pyridinyl]-N-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester; Boc2-6-Bromomethyl-2-aminopyridine; Di-Boc-6-Bromomethyl-2-aminopyridine; N,N-Bis(tert-butoxycarbonyl)-6-(bromomethyl)pyridin-2-amine; (6-(Bromomethyl)pyridin-2-yl)bis(tert-butoxycarbonyl)amine; tert-Butyl (6-(bromomethyl)pyridin-2-yl)(tert-butoxycarbonyl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl N-[6-(Bromomethyl)-2-Pyridyl]-N-tert-butoxycarbonyl-carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.