Description

Carbamic Acid, n-Methyl-n-[2-(Trimethylsilyl)Ethynyl]-, Methyl Ester is a specialized organosilicon building block featuring a carbamate-protected amine and a trimethylsilyl-protected acetylene (TMS-acetylene) moiety. This compound is valued for its dual functionality, serving as a versatile synthon in advanced organic synthesis, particularly for constructing complex molecular architectures. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry, cross-coupling reactions, and the development of novel polymers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring alkyne or protected amine functionalities.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactive acetylene group for structural diversification.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and silicon-containing advanced materials.
• Organic Synthesis: A versatile reagent for Sonogashira and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Chemical Biology: Employed in the synthesis of probes and linkers for bioconjugation and labeling studies due to its click chemistry-compatible alkyne group.
• Protecting Group Strategy: The TMS and carbamate groups provide orthogonal protection for amines and alkynes, useful in multi-step synthetic sequences.

Basic Information

Product Name	Carbamic Acid, n-Methyl-n-[2-(Trimethylsilyl)Ethynyl]-, Methyl Ester
CAS No.	888015-57-4
Molecular Formula	C9H17NO2Si
Molecular Weight	199.32 g/mol
Synonyms	Methyl N-Methyl-N-[2-(trimethylsilyl)ethynyl]carbamate; N-Methyl-N-(2-(trimethylsilyl)ethynyl)carbamic Acid Methyl Ester; TMS-Ethynyl Methyl Methylcarbamate; (Trimethylsilyl)acetylene Carbamate Derivative; Propargyl Carbamate TMS Derivative; CAS 888015-57-4
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, n-Methyl-n-[2-(Trimethylsilyl)Ethynyl]-, Methyl Ester adheres to stringent quality protocols suitable for research and industrial-scale applications. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.