Description

6-(2,5-Difluorophenyl)Pyridine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its difluorophenyl and pyridine-carboxylic acid functional groups. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of new drug candidates, especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the difluorophenyl moiety enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and metal-organic frameworks (MOFs) due to its rigid, aromatic structure.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags or bioactive probes in diagnostic and research applications.
• Custom Synthesis and Contract Manufacturing: Supplied for bespoke chemical synthesis projects requiring high-fidelity fluorinated heterocycles.

Basic Information

Product Name	6-(2,5-Difluorophenyl)Pyridine-2-Carboxylic Acid
CAS No.	887983-00-8
Molecular Formula	C12H7F2NO2
Molecular Weight	235.19 g/mol
Synonyms	2,5-Difluoro-6-(2-pyridinyl)benzoic Acid; 6-(2,5-Difluorophenyl)picolinic Acid; 2-Pyridinecarboxylic acid, 6-(2,5-difluorophenyl)-; Picolinic acid, 6-(2,5-difluorophenyl)-; 6-(2,5-Difluorophenyl)-2-pyridinecarboxylic acid; 887983-00-8; AI3-63575
EINECS	Contact for details

Quality Control

Our 6-(2,5-Difluorophenyl)Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.