Description

1-[8-(4-Fluorophenyl)-1,4-Dioxaspiro[4.5]Dec-8-Yl]Methanamine is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure and fluorinated aromatic moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: Key synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile functional groups.
• API Development: Serves as a crucial precursor in the production of Active Pharmaceutical Ingredients (APIs) for clinical trials and commercial manufacturing.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1-[8-(4-Fluorophenyl)-1,4-Dioxaspiro[4.5]Dec-8-Yl]Methanamine
CAS No.	887979-07-9
Molecular Formula	C₁₇H₂₂FNO₂
Molecular Weight	291.36 g/mol
Synonyms	8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decane-8-methanamine; 1-[8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]dec-8-yl]methanamine; (8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-yl)methanamine; 4-Fluorophenyl spiroketal amine; FPDM Intermediate; Spiro[4.5]decane-8-methanamine, 8-(4-fluorophenyl)-1,4-dioxa-; CAS 887979-07-9
EINECS	Contact for details

Quality Control

Our 1-[8-(4-Fluorophenyl)-1,4-Dioxaspiro[4.5]Dec-8-Yl]Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for advanced research and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.