Description

1-[8-(3,4-Dimethoxyphenyl)-1,4-Dioxaspiro[4.5]Dec-8-Yl]Methanamine is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and dimethoxyphenyl structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting neurological and cardiovascular therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel central nervous system (CNS) and cardiovascular drugs.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules in pilot and commercial manufacturing.
• Academic Research: Serves as a specialized reagent for studying spirocyclic compound synthesis and reactivity in university and institutional labs.
• Contract Research Organizations (CROs): Utilized in custom synthesis and development services for client-specific molecular targets.
• Bioconjugation & Probe Development: The primary amine functionality allows for conjugation, making it suitable for creating biochemical probes and labeled compounds.

Basic Information

Product Name	1-[8-(3,4-Dimethoxyphenyl)-1,4-Dioxaspiro[4.5]Dec-8-Yl]Methanamine
CAS No.	887978-91-8
Molecular Formula	C19H27NO4
Molecular Weight	333.43 g/mol
Synonyms	1-[8-(3,4-Dimethoxyphenyl)-1,4-dioxaspiro[4.5]dec-8-yl]methanamine; 8-(Aminomethyl)-8-(3,4-dimethoxyphenyl)-1,4-dioxaspiro[4.5]decane; (8-(3,4-Dimethoxyphenyl)-1,4-dioxaspiro[4.5]dec-8-yl)methanamine; 1,4-Dioxaspiro[4.5]decane-8-methanamine, 8-(3,4-dimethoxyphenyl)-; Spirocyclic Dimethoxyphenyl Methanamine Intermediate; CAS 887978-91-8
EINECS	Contact for details

Quality Control

Our 1-[8-(3,4-Dimethoxyphenyl)-1,4-Dioxaspiro[4.5]Dec-8-Yl]Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.