Description

(6-[3-(Trimethylsilyl)Phenyl]Pyridin-3-Yl)Methanol is a high-purity, functionalized organosilicon-pyridine hybrid compound that serves as a critical building block in advanced organic synthesis. Its unique structure, combining a silyl-protected aromatic system with a hydroxymethylpyridine moiety, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, particularly for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Ligand Precursor: Serves as a starting material for synthesizing sophisticated chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Used in the synthesis of new-generation pesticides and herbicides, leveraging its silicon-containing aromatic system for enhanced bioactivity and environmental stability.
• Advanced Material Synthesis: Building block for organic semiconductors, liquid crystals, and photoactive materials where the trimethylsilyl group modulates solubility and electronic properties.
• Cross-Coupling Reactions: The functional groups present make it a suitable substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Protecting Group Strategy: The trimethylsilyl moiety can be utilized as a protecting group or as a latent functionality in multi-step synthetic sequences.

Basic Information

Product Name	(6-[3-(Trimethylsilyl)Phenyl]Pyridin-3-Yl)Methanol
CAS No.	887974-82-5
Molecular Formula	C15H19NOSi
Molecular Weight	257.40 g/mol
Synonyms	3-Pyridinemethanol, 6-[3-(trimethylsilyl)phenyl]-; [6-(3-Trimethylsilylphenyl)pyridin-3-yl]methanol; (6-(3-(Trimethylsilyl)phenyl)pyridin-3-yl)methanol; 6-(3-Trimethylsilylphenyl)nicotinyl alcohol; 6-(3-TMS-phenyl)pyridin-3-yl-methanol; TMS-Phenyl-Pyridine Methanol Derivative; 887974-82-5 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of (6-[3-(Trimethylsilyl)Phenyl]Pyridin-3-Yl)Methanol is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, which are designed to meet the exacting requirements of research and process development. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurity profiles is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.