Description

5-[2-(Trifluoromethyl)Phenyl]Nicotinaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethylphenyl-substituted nicotinaldehyde structure. This compound is critical for enabling the synthesis of novel, complex molecules, particularly in medicinal chemistry where the introduction of fluorine atoms can dramatically alter a compound's metabolic stability, lipophilicity, and binding affinity. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the creation of novel pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for the synthesis of specialized ligands and organic electronic materials.
• Chemical Biology Probes: Employed in the design of molecular probes and fluorinated tags for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	5-[2-(Trifluoromethyl)Phenyl]Nicotinaldehyde
CAS No.	887973-91-3
Molecular Formula	C13H8F3NO
Molecular Weight	251.21 g/mol
Synonyms	5-[2-(Trifluoromethyl)phenyl]pyridine-3-carbaldehyde; 3-Formyl-5-[2-(trifluoromethyl)phenyl]pyridine; Nicotinaldehyde, 5-[2-(trifluoromethyl)phenyl]-; 5-(2-(Trifluoromethyl)phenyl)nicotinaldehyde; 5-(α,α,α-Trifluoro-o-tolyl)nicotinaldehyde
EINECS	Contact for details

Quality Control

Our 5-[2-(Trifluoromethyl)Phenyl]Nicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.