Description

5-[3-(Trifluoromethyl)Phenyl]Nicotinaldehyde is a high-value fluorinated aromatic aldehyde building block. This compound matters for its unique trifluoromethylphenyl and pyridine aldehyde functionalities, which are critical for modulating the physicochemical properties of advanced molecules. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethyl group enhances bioactivity and metabolic stability.
• Material Science Research: Serves as a precursor for creating specialized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The aldehyde group is amenable to further functionalization via reactions like reductive amination or condensation, enabling rapid library synthesis.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) influenced by the trifluoromethyl moiety.

Basic Information

Product Name	5-[3-(Trifluoromethyl)Phenyl]Nicotinaldehyde
CAS No.	887973-63-9
Molecular Formula	C13H8F3NO
Molecular Weight	251.21 g/mol
Synonyms	5-[3-(Trifluoromethyl)phenyl]pyridine-3-carbaldehyde; 3-Formyl-5-[3-(trifluoromethyl)phenyl]pyridine; Nicotinaldehyde, 5-[3-(trifluoromethyl)phenyl]-; 5-(3-Trifluoromethylphenyl)nicotinaldehyde; 5-(m-Trifluoromethylphenyl)nicotinaldehyde; 3-Pyridinecarboxaldehyde, 5-[3-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 5-[3-(Trifluoromethyl)Phenyl]Nicotinaldehyde is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.