Description

5-[4-(Trifluoromethoxy)Phenyl]Nicotinaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethoxy-substituted aromatic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapeutics, particularly in the areas of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers and liquid crystals with specific optical or electronic properties.
• Chemical Synthesis: Acts as a versatile aldehyde component in cross-coupling reactions, condensations, and reductive amination for constructing complex molecular architectures.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploratory research in organic and medicinal chemistry.

Basic Information

Product Name	5-[4-(Trifluoromethoxy)Phenyl]Nicotinaldehyde
CAS No.	887973-59-3
Molecular Formula	C13H8F3NO2
Molecular Weight	267.21 g/mol
Synonyms	5-[4-(Trifluoromethoxy)phenyl]pyridine-3-carbaldehyde; 3-Pyridinecarboxaldehyde, 5-[4-(trifluoromethoxy)phenyl]-; Nicotinaldehyde, 5-[4-(trifluoromethoxy)phenyl]-; 5-(4-Trifluoromethoxyphenyl)nicotinaldehyde; 5-(4-(Trifluoromethoxy)phenyl)pyridine-3-carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 5-[4-(Trifluoromethoxy)Phenyl]Nicotinaldehyde is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets a typical purity specification of ≥97% (by HPLC), with specifications tailored for research and development or GMP manufacturing needs. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.