Description

5-[2-(Trifluoromethyl)Phenyl]Nicotinic Acid is a high-purity, multi-functional organic building block characterized by its trifluoromethylphenyl and nicotinic acid functional groups. This compound is critical for advanced research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by pharmaceutical R&D laboratories, agrochemical manufacturers, and specialty chemical producers for creating complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its aromatic and fluorinated structure.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and inhibitors for studying enzyme function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific fluorinated aromatic architectures.

Basic Information

Product Name	5-[2-(Trifluoromethyl)Phenyl]Nicotinic Acid
CAS No.	887973-54-8
Molecular Formula	C13H8F3NO2
Molecular Weight	267.20 g/mol
Synonyms	5-[2-(Trifluoromethyl)phenyl]pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-[2-(trifluoromethyl)phenyl]-; Nicotinic acid, 5-[2-(trifluoromethyl)phenyl]-; 2'-(Trifluoromethyl)-[3,3'-bipyridine]-5-carboxylic acid (tautomeric form); 5-(2-Trifluoromethylphenyl)nicotinic acid
EINECS	Contact for details

Quality Control

Our 5-[2-(Trifluoromethyl)Phenyl]Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.